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Coincidence of HCV and chronic kidney disease-a systematic review and meta-analysis

Rabia Nawaz1,2, Muhammad Ahmad3, Muhammad Saad Raza3

  • 1Department of Biological Sciences, Superior University, Lahore, 53700, Pakistan. dr.rabia.nawaz8@gmail.com.

BMC Public Health
|October 16, 2024
PubMed

Insights

Hepatitis C virus (HCV) infection is linked to an increased risk of developing chronic kidney disease (CKD) in the general population. This systematic review confirms a significant correlation, highlighting the importance of monitoring kidney health in HCV patients.

Area of Science:

  • Nephrology
  • Hepatology
  • Epidemiology

Background:

  • Hepatitis C virus (HCV) infection is a known risk factor for various health complications.
  • The association between HCV and chronic kidney disease (CKD) has been reported, but its impact on the general population remains unclear.

Purpose of the Study:

  • To investigate the link between positive anti-HCV serologic status and the incidence of CKD in the general adult population.
  • To quantify the relative risk of CKD associated with HCV infection through a systematic literature review.

Main Methods:

  • A systematic review of published medical literature from 2015 onwards was conducted.
  • Meta-analyses, stratified analyses, and meta-regression were employed to estimate the risk of CKD in HCV-positive individuals.
  • Data from 12 studies encompassing 605,858 patients were analyzed.

Main Results:

  • The pooled analysis of longitudinal studies (347,120 patients) revealed a significant association between HCV infection and increased CKD incidence.
  • The summary estimate for the adjusted hazard ratio of CKD in HCV-positive individuals was 1.21 (95% CI: 1.13–1.29, P=0.001).
  • A higher risk of CKD (HR=1.70) was observed in Asian populations, with no significant heterogeneity.

Conclusions:

  • Hepatitis C virus infection is strongly correlated with an elevated risk of developing chronic kidney disease.
  • The findings underscore the importance of considering HCV status in the assessment and management of CKD risk in the general population.
Abstract

Keywords:
Chronic kidney diseaseEnd stage renal diseaseHCVIncidence rate ratioNewcastle ottawa Scale

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