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Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
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Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
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Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Ionic flow through partially blocked nanopores.

Sipra Mohapatra1, Hema Teherpuria1, Santosh Mogurampelly1

  • 1Polymer Electrolytes and Materials Group (PEMG), Department of Physics, Indian Institute of Technology Jodhpur, N.H. 62, Nagaur Road, Karwar, Jodhpur, Rajasthan 342030, India.

Physical Chemistry Chemical Physics : PCCP
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PubMed
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Ionic conductivity in blocked nanopores depends on surface charge and pore size. Ion behavior, especially for potassium (K+) and chloride (Cl-) ions, is sensitive to pore dimensions and charge polarity.

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Area of Science:

  • Physical Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Understanding ionic transport in confined systems is crucial for applications like desalination and energy storage.
  • Nanopores with constrictions present unique challenges and opportunities for controlling ion flow.

Purpose of the Study:

  • To investigate ionic conductivity mechanisms in partially blocked nanopores.
  • To explore the influence of pore diameter, surface charge, and blockage size on ion transport.

Main Methods:

  • Atomistic molecular dynamics (MD) simulations were employed.
  • Simulations analyzed ionic mobilities, free energy profiles, and current flow.

Main Results:

  • Ionic mobilities are significantly affected by surface charge polarity and pore gap size.
  • Ion-specific effects for K+ and Cl- were observed, particularly in sub-nanometer pores.
  • Current flow is sensitive to surface charges and constriction volume, with effects amplified when blockage and pore sizes are comparable.

Conclusions:

  • Surface charge and pore geometry are key factors governing ionic conductivity in partially blocked nanopores.
  • Ion size and charge play a critical role in transport through narrow constrictions.
  • The findings provide insights into designing nanoporous materials for selective ion transport.