Correlation Between Anxiety, Depression and Hemodynamic Changes in Office-Based Laryngeal Surgery

To investigate the correlation between anxiety, depression, and hemodynamic changes during office-based laryngeal surgery (OBLS).

All patients undergoing OBLS between February 2024 until July 2024 were invited to participate in the study. Participants had their vital signs recorded throughout the procedure at a 5-min interval. They also had to fill the Generalized Anxiety Disorder scale-7 (GAD-7) to assess anxiety severity and the Patient Health Questionnaire-9 (PHQ-9) to assess depression severity. Demographic data included age, gender, history of smoking, history of reflux disease, history of cardiovascular diseases, type and duration of procedure.

A total of 45 patients were recruited in the study. During OBLS, 35.5% of patients developed hypertension and 28.9% developed tachycardia. There was a significant increase in mean systolic blood pressure (SBP) by 30.16 mmHg (p < 0.001), in mean diastolic blood pressure (DBP) by 31.44 mmHg (p < 0.001), and in mean heart rate (HR) by 14.2 beats per minute (p < 0.001). There was also a significant decrease in the mean O₂ saturation by 0.4% (p = 0.001). There was no correlation between anxiety and SBP, DBP, HR, and O₂ (r < 0.1). There was also no correlation between depression levels and SBP, DBP, HR, O₂ (r < 0.1).

There was a significant increase in the mean SBP, DP, and HR and a significant decrease in the O₂ saturation in patients undergoing OBLS. However, there was no correlation between anxiety, depression and the changes in these vital signs. Future investigations are needed to understand the causes of hemodynamic instability in OBLS.

2 Laryngoscope, 135:818-822, 2025.