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Food intake enhances hippocampal sharp wave-ripples.
Ekin Kaya1, Evan Wegienka1, Alexandra Akhtarzandi-Das1
1Department of Psychology, University of Michigan, Ann Arbor, MI, 48109, USA.
Biorxiv : the Preprint Server for Biology
|October 17, 2024
Summary
Feeding enhances hippocampal sharp wave ripples (SWRs), crucial for memory and metabolism. This feeding-dependent SWR increase signals to the lateral hypothalamus, impacting energy balance and food intake regulation.
Area of Science:
- Neuroscience
- Metabolic Regulation
- Neurobiology
Background:
- The hypothalamus regulates energy metabolism and homeostasis.
- The hippocampus, involved in memory, also influences metabolic control.
- Hippocampal sharp wave ripples (SWRs) affect glucose levels, but their modulation by feeding is unknown.
Purpose of the Study:
- Investigate if feeding enhances hippocampal SWRs.
- Determine if SWRs are modulated by meal caloric content.
- Examine communication between the hippocampus and lateral hypothalamus regarding feeding status.
Main Methods:
- Recorded SWRs from the dorsal CA1 region of mouse hippocampus during sleep.
- Administered meals with varying caloric values under different feeding conditions.
- Measured activity in lateral hypothalamic GABAergic neurons.
Main Results:
- Sleep-dependent SWRs significantly increased after food intake.
- SWR enhancement magnitude correlated with meal caloric content.
- Lateral hypothalamic GABAergic neurons showed increased activity triggered by SWRs.
Conclusions:
- Satiety state modulates hippocampal SWRs.
- Hippocampal-lateral hypothalamic communication is a potential pathway for metabolic regulation.
- SWRs may influence peripheral metabolism and food intake via this pathway.
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