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Sharpless Epoxidation

Sharpless Epoxidation

The conversion of allylic alcohols into epoxides using the chiral catalyst was discovered by K. Barry Sharpless and is known as Sharpless epoxidation. The use of a chiral catalyst enables the formation of one enantiomer of the product in excess. This chiral catalyst is mainly a chiral complex of titanium tetraisopropoxide and tartrate ester (specific stereoisomer). The stereoisomer used in the chiral catalyst dictates the formation of the enantiomer of the product. In other words, the use of...

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"Real-world" performance of the Confirm Rx™ SharpSense AF detection algorithm: UK Confirm Rx study.

Andre Briosa E Gala^1,2, Michael T B Pope³, Milena Leo¹

¹Department of Cardiology Oxford University Hospitals NHS Foundation Trust Oxford UK.

Journal of Arrhythmia

|October 17, 2024

Summary

This summary is machine-generated.

The Confirm Rx™ implantable cardiac monitor showed modest diagnostic performance for atrial fibrillation (AF) detection, with accuracy improving for longer AF episodes. This study evaluated its effectiveness in detecting AF using SharpSense™ technology and a P-wave discriminator.

Keywords:

ambulatory monitoring arrhythmia monitoring atrial fibrillation implantable cardiac monitor implantable loop recorders

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Area of Science:

Cardiology
Medical Devices
Digital Health

Background:

The Confirm Rx™ implantable cardiac monitor (ICM) features SharpSense™ technology and a new P-wave discriminator to enhance atrial fibrillation (AF) detection.
Accurate AF detection is crucial for timely treatment and stroke prevention.

Purpose of the Study:

To evaluate the diagnostic performance of the Confirm Rx™ ICM in detecting AF episodes of varying durations.
To assess the impact of episode duration on the monitor's accuracy.

Main Methods:

A multicenter retrospective analysis of 232 patients with documented AF was conducted.
Electrocardiograms (ECGs) from Confirm Rx™ ICMs were manually adjudicated by cardiologists.
Positive predictive value (PPV) for AF episodes of different durations was calculated.

Main Results:

The overall gross and patient-averaged PPV for AF detection were 75.0% and 67.0%, respectively.
Diagnostic performance improved with longer AF episodes: 88.0% for ≥1 hour, 97.3% for 6 hours, and 100% for 24 hours.
T-wave oversensing and ectopy were primary sources of false positives.

Conclusions:

The Confirm Rx™ ICM demonstrates modest overall diagnostic performance for AF detection.
Accuracy significantly increases with longer AF episode durations.
The device's performance is influenced by factors like T-wave oversensing and ectopy.