Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Modular Liver-Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites.

Advanced healthcare materials·2026

Same author

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026

Same author

A framework for building a synthetic cell from the SynCell Asia Initiative.

Nature biotechnology·2026

Same author

Engineered commensals for metabolic modulation of the gut-liver-brain axis.

Cell·2026

Same author

Morphological and Morphometric Analysis of the Pterion and Its Neurosurgical Implications.

Cureus·2026

Same author

Microbial chassis selection for niche-specific engineered live biotherapeutics.

Current opinion in microbiology·2026

Search research articles

Related Experiment Video

Updated: May 3, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

Organ-on-chip technology: Opportunities and challenges.

Santosh Kumar Srivastava^1,2,3, Guo Wei Foo^1,2,4,3, Nikhil Aggarwal^1,2,3

¹NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore.

Biotechnology Notes (Amsterdam, Netherlands)

|October 17, 2024

Summary

Organ-on-chip (OOC) technology offers advanced in vitro models for biomedical research and drug screening. This review compares OOCs to traditional methods, highlighting their potential to revolutionize physiological studies.

Keywords:

2D/3D culture models Gut-on-Chip Kidney-on-chip Liver-on-chip Lung-on-chip Microfluidics Organs-on-chips (OOCs)

More Related Videos

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Related Experiment Videos

Last Updated: May 3, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Area of Science:

Biomedical Engineering
Physiology
Microfluidics

Background:

Organ-on-chip (OOC) technology replicates human organ functions on microfluidic chips.
OOCs offer superior insights compared to traditional in vitro and in vivo models.
This technology is poised to become a new standard in research and drug development.

Purpose of the Study:

To compare OOC technology with conventional research models.
To present diverse applications of OOCs in biomedical research.
To discuss advancements, challenges, and future directions in OOC development.

Main Methods:

Comparative analysis of OOCs versus traditional models.
Review of current OOC applications in various research fields.
Exploration of recent technological advancements, including multi-organ systems.

Main Results:

OOCs provide unique advantages over conventional models for studying physiological processes.
Numerous applications demonstrate the utility of OOCs in biomedical research.
Significant progress has been made in developing complex, multi-organ OOC systems.

Conclusions:

OOC technology represents a significant advancement in biomedical research and drug screening.
Further development in multi-organ systems and addressing current challenges will enhance OOC capabilities.
OOCs are expected to play a pivotal role in the future of human health research.