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Characterizing biomolecular structure features through an innovative elliptical dichroism spectrometry for cancer

Yusuf Asad¹, Keerthi Priya Jangili¹, Amara Arshad²

¹Biomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, United States.

|October 17, 2024

Abstract:

This research introduces a novel method for evaluating the structural features of biomolecules, utilizing our innovative Elliptical Dichroism (ED) spectrometer specifically designed for stereochemical analysis. By integrating ED spectrometry with autocorrelation (AC) analysis, we investigate the conformational characteristics of biological molecules such as amino acids, proteins, and extracellular vesicles (EVs) induced by elliptically polarized UV absorption. Our streamlined approach offers a cost-effective and portable solution with minimal sample consumption and supports multiple working modes to efficiently characterize biomolecular structures. The insight from this new approach demonstrates potential applications in using biomolecular characterization for cancer detection.

Keywords:

Autocorrelation function Density-functional theory Elliptical dichroism Molecular dynamics simulation Spectrometer Stereochemical analysis Tumor differentiation

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