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Updated: Jun 10, 2025
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Pathogenesis and Systemic Treatment of Hepatocellular Carcinoma: Current Status and Prospects
Wanting Lei1, Kexun Zhou1, Ye Lei2
1Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Abstract:
Hepatocellular carcinoma (HCC) remains one of the major threats to human health worldwide. The emergence of systemic therapeutic options has greatly improved the prognosis of patients with HCC, particularly those with advanced stages of the disease. In this review, we discussed the pathogenesis of HCC, genetic alterations associated with the development of HCC, and alterations in the tumor immune microenvironment. Then, important indicators and emerging technologies related to the diagnosis of HCC are summarized. Also, we reviewed the major advances in treatments for HCC, offering insights into future prospects for next-generation managements.
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