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Updated: Jun 10, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Recent Progress on NHC-Catalyzed 1,6-Conjugate Addition Reactions
Jun Sun1, Shichun Jiang1, Yonggui Liu1
1College of Chemistry and Chemical Engineering, Guizhou University of Engineering Science, Xueyuan Road, Qixingguan District, Bijie, 551700, China.
Abstract:
As a significant variant of the Michael reaction, the 1,6-addition reaction has undergone considerable development over the past decade. This effective strategy enables the synthesis of a variety of novel and potentially bioactive functional molecules. In this review, we summarize the recent progress in NHC-catalyzed 1,6-addition reactions, highlighting their efficiency in the rapid synthesis of complex functional molecules. We also provide our perspectives on the future development of this dynamic and highly active research area.
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