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Updated: Jun 10, 2025

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Viruses and Mitochondrial Dysfunction in Neurodegeneration and Cognition: An Evolutionary Perspective
George B Stefano1, Simon Weissenberger2, Radek Ptacek3
1Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, 120 00, Prague, Czech Republic. gstefano@sunynri.org.
Abstract:
Mitochondria, the cellular powerhouses with bacterial evolutionary origins, play a pivotal role in maintaining neuronal function and cognitive health. Several viruses have developed sophisticated mechanisms to target and disrupt mitochondrial function which contribute to cognitive decline and neurodegeneration. The interplay between viruses and mitochondria might be traced to their co-evolutionary history with bacteria and may reflect ancient interactions that have shaped modern mitochondrial biology.
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