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Published on: June 5, 2017
The IL-4-IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell
Yannis Hara1, Mithilesh Kumar Jha1, Jeremy Y Huang2
1Type 2 Inflammation, Immunology and Inflammation, Sanofi, Cambridge, Massachusetts, USA.
Abstract:
IL-4 and IL-13 have non-redundant effects in olfaction, with loss of smell in mice evoked only by intranasal administration of IL-4, but not IL-13. IL-4-evoked pathophysiological effects on olfaction is independent of compromised structural integrity of the olfactory neuroepithelium. IL-4-IL-4Rα signaling modulates neuronal crosstalk with immune cells, suggesting a functional link between olfactory impairment and neuroinflammation. Abbreviations: IL, interleukin; KO, knock-out; wk, week; WT, wild-type.
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