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Updated: Jun 10, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Gram-Scale Synthesis of the Fucose-Containing Fragments of Saccharomicins
Dengxian Fu1, Ting Li1, Shiwei Xu1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, People's Republic of China.
Abstract:
A highly efficient synthetic route has been established for the gram-scale production of fucose-aglycon (Fuc-Agl) and fucose-saccharosamine (Fuc-Sac) fragments in saccharomicins A and B. The β-glycosidic bonds within these structural components were formed through successive rhodium(II) and Brønsted-acid-catalyzed glycosylation, utilizing a stable thioglycosyl donor. Subsequent steps involving the installation of protecting groups yielded highly functionalized synthetic fragments that are suitable for further assembly of saccharomicins.
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