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Sickle-cell nephropathy: MR imaging.

I M Lande, G M Glazer, S Sarnaik

    Radiology
    |February 1, 1986
    PubMed
    Summary
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    Sickle-cell disease (SCD) patients show unique kidney changes on MR imaging, possibly due to abnormal iron metabolism in the renal cortex, not just systemic iron overload.

    Area of Science:

    • Nephrology
    • Radiology
    • Hematology

    Background:

    • Sickle-cell disease (SCD) can lead to kidney complications, known as sickle-cell nephropathy.
    • Systemic iron overload is common in transfusion-dependent anemias like SCD and beta-thalassemia major (BTM).

    Purpose of the Study:

    • To investigate renal changes in SCD patients using magnetic resonance (MR) imaging.
    • To differentiate MR imaging findings in SCD from those in BTM and healthy controls, exploring the role of iron metabolism.

    Main Methods:

    • Spin-echo MR imaging of the kidneys was performed on 19 SCD patients, 6 BTM patients, and 10 healthy controls.
    • Analysis focused on renal cortical signal intensity, particularly on T2-weighted images.

    Main Results:

    Related Experiment Videos

    • Eleven SCD patients exhibited decreased relative renal cortical signal intensity, most apparent on T2-weighted MR images.
    • No correlation was found between diminished cortical signal and serum ferritin, urine concentration, BUN, or creatinine levels.
    • Beta-thalassemia major patients, despite iron overload, did not show diminished renal cortical signal.

    Conclusions:

    • Diminished renal cortical signal in SCD patients may be linked to iron deposition or altered iron metabolism within the renal cortex.
    • These findings suggest that renal MR imaging abnormalities in SCD are specific to the disease and not solely a consequence of systemic iron overload.