Related Experiment Video
Updated: Jun 10, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Digital cognitive-behavioral therapy for insomnia in patients with multiple sclerosis: A multiple baseline
Sven Alfonsson1, Alva Olofsson Liljeholm2, Camilla Adel3
1Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Video-based cognitive behavioral therapy for insomnia (VCBT-I) effectively treated insomnia in multiple sclerosis (MS) patients. This approach improved sleep, reduced depression and anxiety, and enhanced quality of life for individuals with MS and insomnia.
Area of Science:
- Neurology
- Sleep Medicine
- Psychiatry
Background:
- Insomnia affects over 20% of multiple sclerosis (MS) patients.
- Cognitive Behavioral Therapy for Insomnia (CBT-I) shows promise for MS-related sleep issues.
- Video-based CBT-I (VCBT-I) offers a remote, accessible treatment option.
Purpose of the Study:
- To assess the efficacy of VCBT-I in patients with comorbid insomnia and MS.
- To evaluate the impact of VCBT-I on sleep quality, psychological symptoms, and quality of life.
Main Methods:
- Pilot study involving ten participants with MS and insomnia.
- Utilized video-based cognitive behavioral therapy for insomnia (VCBT-I).
- Assessed outcomes using Insomnia Severity Index (ISI), PHQ-9 (depression), and GAD-7 (anxiety).
Main Results:
- Significant reductions in total wake time observed in 60% of participants.
- Clinically significant improvements in waking time for 70% of participants.
- Eight participants achieved insomnia remission based on ISI scores.
- Observed improvements in depression and anxiety symptoms.
- Participants reported enhanced quality of life and high treatment satisfaction.
Conclusions:
- VCBT-I is a well-tolerated and effective treatment for insomnia in individuals with MS.
- This modality shows potential for alleviating sleep disturbances and associated psychological symptoms.
- Further research may be needed to optimize fatigue management within VCBT-I for MS patients.
More Related Videos
Related Concept Videos
Management of Insomnia
Insomnia
Multiple factors contribute...
REM Sleep Behavior Disorder
RBD is significantly associated with...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Narcolepsy
CNS Depressants: Barbiturates and Benzodiazepines

