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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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Label-free Single Molecule Detection Using Microtoroid Optical Resonators
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A ring resonators optical sensor for multiple biomarkers detection.

Rachele Favaretto1, Niccolò Ardoino2, Georg Pucker3

  • 1FTH srl, Via Sommarive 18, 38123, Trento, Italy; Department of Physics, University of Trento, Via Sommarive 14, 38123, Trento, Italy.

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|October 17, 2024
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Summary
This summary is machine-generated.

A new photonic integrated circuit enables rapid, simultaneous detection of disease biomarkers like C-Reactive Protein (CRP) and Creatine-Kinase-MB (CK-MB) using microring resonators (MRRs) for advanced Point-Of-Care-Tests (POCTs).

Keywords:
BiomarkersImmunosensorsMolecular diagnosticsMultiplexPOCTsPhotonic chip

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Area of Science:

  • Photonics and Biomedical Engineering
  • Integrated Optics
  • Biosensing Technology

Background:

  • Point-of-Care-Tests (POCTs) are increasingly vital for rapid clinical diagnostics, offering near-patient testing for improved patient outcomes.
  • Technological advancements in miniaturization and instrumentation have driven the development of smaller, more accurate POCT devices.
  • Simultaneous screening of multiple analytes enhances diagnostic specificity and disease characterization.

Purpose of the Study:

  • To develop and characterize a photonic integrated circuit for multiplexed biomarker detection.
  • To create the core component for a fully developed POCT device for clinical pathology.
  • To demonstrate parallel detection of C-Reactive Protein (CRP) and Creatine-Kinase-MB (CK-MB) using the developed sensor.

Main Methods:

  • Fabrication of a photonic sensor based on microring resonators (MRRs).
  • Functionalization of MRR surfaces with antibodies immobilized on a copolymer layer.
  • Surface chemical analysis and fluorescence microscopy for surface characterization.
  • Characterization of the sensor's performance for parallel CRP and CK-MB detection in buffer and artificial saliva.

Main Results:

  • Achieved high sensitivity with a limit of detection (LOD) of 103 pM for CRP and 140 pM for CK-MB.
  • Demonstrated promising specificity for parallel biomarker detection.
  • Obtained analyte-antibody binding curves in both buffer and artificial saliva samples.
  • Validated the sensor's capability for multiplexed detection in a relevant biological matrix.

Conclusions:

  • The developed photonic integrated circuit serves as a highly sensitive core for POCT devices.
  • The sensor demonstrates potential for rapid, multiplexed molecular diagnostics in clinical settings.
  • These findings pave the way for advanced POCT devices with improved diagnostic capabilities.