Hermansones A and B: Bioactive naphthazarin congeners from the European crust fungus Hermanssonia centrifuga
Winnie Chemutai Sum1, Sherif S Ebada2, Jackson M Muema3
1Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI) and German Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany; Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
Abstract:
Two previously undescribed naphthazarins named hermansones A (1) and B (2), were isolated from the wood-decaying basidiomycete Hermanssonia centrifuga. The study presents the first report of natural products from the species. The structures of the secondary metabolites were elucidated through NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 was elucidated using TDDFT-ECD calculations. Hermansone B (2) demonstrated moderate inhibitory effects against Chikungunya virus at IC50 of 55.97 μM, without inducing notable cytotoxicity.
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