Identifying standardised neuropsychological test measures sensitive to cannabis consumption: A systematic review

While numerous studies have indicated acute neurocognitive changes following the administration of Δ9-tetrahydrocannabinol (THC; the psychoactive component of cannabis), the standardised neuropsychological tests most sensitive to THC are yet to be identified. As such, this systematic review analysed scientific evidence (since 2000) on the effects of THC on standardised neuropsychological test measures.

This review was conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were eligible for inclusion if they utilised a between or within-subjects design in testing for differences in standardised neuropsychological test performance following the consumption of THC.

Sufficient data were identified to examine 8 standardised neuropsychological test measures, with 12 studies being eligible for inclusion in the review. It was identified that the Cambridge Neuropsychological Test Automated Battery (CANTAB) subtest Spatial Working Memory, Hopkins Verbal Learning Test, Prose Recall and Rey Auditory Verbal Learning Test were sensitive to cannabis consumption.

However, due to substantial variability observed across studies, the data could not be quantitatively analysed. It was noted that few studies employed standardised neuropsychological measures in assessing the effects of THC.

Overall, the findings highlight the need for further research examining the effects of cannabis on standardised and validated measures of neurocognitive function. Such an approach can be considered an important first step towards developing behavioural measures of impairment.