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Neutropenia possibly caused by cefoperazone/sulbactam.
Yun Li1, Xiao Fang He1, Ran Wang2
1Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, Jiangsu Province, China.
European Journal of Hospital Pharmacy : Science and Practice
|October 17, 2024
Summary
Drug-induced neutropenia is rare. Cefoperazone/sulbactam, an antibiotic, can cause neutropenia. Monitoring neutrophil counts during treatment is crucial for early detection and management.
Area of Science:
- Infectious Diseases
- Pharmacology
- Hematology
Background:
- Neutropenia is an uncommon but serious adverse effect of certain medications.
- Data regarding neutropenia specifically induced by cefoperazone/sulbactam is limited.
- Cefoperazone/sulbactam is a widely used broad-spectrum antibiotic combination.
Purpose of the Study:
- To report a case of neutropenia associated with cefoperazone/sulbactam therapy.
- To highlight the importance of monitoring neutrophil counts in patients receiving this antibiotic combination.
Main Methods:
- Case report of a 35-year-old female patient.
- Treatment of an appendiceal abscess with cefoperazone/sulbactam.
- Monitoring of white blood cell and neutrophil counts during treatment.
Main Results:
- The patient developed neutropenia on day 4 of cefoperazone/sulbactam administration.
- Discontinuation of cefoperazone/sulbactam led to the normalization of white blood cell and neutrophil counts.
- The patient recovered fully after cessation of the antibiotic.
Conclusions:
- Cefoperazone/sulbactam can induce neutropenia.
- Close monitoring of neutrophil counts is recommended during cefoperazone/sulbactam therapy.
- Prompt intervention upon detecting neutropenia is essential for patient recovery.
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