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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
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Recent advances in chitosan-based smart hydrogel for drug delivery systems
Aiman Salahuddin1, Azqa Ashraf1, Khurshid Ahmad1
1State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, No.1299, Sansha Road, Qingdao, Shandong Province 266404, PR China.
International Journal of Biological Macromolecules
|October 17, 2024
Summary
Chitosan hydrogels offer sustainable drug delivery with tunable, stimuli-responsive properties. Biomass-derived materials enhance their biocompatibility and controlled release for diverse medical applications.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Sustainable and controllable drug delivery is crucial for effective disease treatment.
- Chitosan hydrogels possess advantageous properties like tunable capacity, controlled degradation, and stimuli sensitivity for drug encapsulation.
- Biomass-derived materials are increasingly favored for chitosan hydrogel construction due to their biodegradability and biocompatibility.
Purpose of the Study:
- To review fabrication methods, properties, and biocompatibility of chitosan hydrogels.
- To explore modification strategies and stimuli-responsive mechanisms for advanced drug delivery.
- To discuss potential applications and future outlook of chitosan-based smart hydrogels.
Main Methods:
- Comprehensive literature review of chitosan hydrogel fabrication and characterization.
- Analysis of stimuli-responsive mechanisms (temperature, pH, light, etc.).
- Evaluation of biocompatibility and degradation properties.
Main Results:
- Chitosan hydrogels offer tunable capacity, controlled degradation, and stimuli sensitivity for drug delivery.
- Biomass-derived chitosan hydrogels exhibit biodegradability, biocompatibility, and non-toxic properties.
- Various stimuli-responsive mechanisms enable finely tuned drug release.
Conclusions:
- Chitosan hydrogels, especially those from biomass, are promising for controlled drug delivery.
- Stimuli-responsive chitosan hydrogels offer versatile applications in subcutaneous, parenteral, oral, and facial delivery.
- Further research is needed to address clinical application challenges and optimize future smart hydrogel designs.
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