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Greater humoral EBV response may be associated with choroid plexus inflammation in progressive MS

Dejan Jakimovski1,2, Robert Zivadinov3,4, Murali Ramanathan5

  • 1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY, 14203, USA. djakimovski@bnac.net.

Journal of Neurovirology
|October 17, 2024
PubMed

Insights

Epstein-Barr Virus (EBV) infection may worsen choroid plexus (CP) neuroinflammation in people with multiple sclerosis (pwMS), particularly in the progressive stage. This suggests a link between EBV and advanced MS pathology.

Area of Science:

  • Neuroimmunology
  • Radiology
  • Infectious Disease

Background:

  • Choroid plexus (CP) inflammation is measurable in multiple sclerosis (MS) using MRI.
  • The association between Epstein-Barr Virus (EBV) and CP changes in MS is not well understood.

Purpose of the Study:

  • To investigate the relationship between EBV humoral response and CP inflammation in people with MS (pwMS).
  • To compare CP characteristics between relapsing-remitting MS (RRMS) and progressive MS (PMS) patients.

Main Methods:

  • 170 pwMS underwent MRI to measure CP volume and pseudo-T2 (pT2) relaxation time.
  • Humoral anti-EBV antibodies (anti-EBNA-1 IgG and anti-VCA IgG) were quantified.
  • Statistical analyses adjusted for age and therapy effects.

Main Results:

  • Progressive MS (PMS) patients exhibited significantly higher CP pT2 values compared to relapsing-remitting MS (RRMS) patients (1120ms vs. 954ms, p=0.037).
  • Higher CP pT2 values correlated with elevated anti-EBNA-1 IgG levels in PMS patients after adjusting for covariates (r=0.352, p=0.015).

Conclusions:

  • An elevated anti-EBV humoral response in pwMS may be linked to increased CP neuroinflammation.
  • This association appears more pronounced in the progressive, later stages of MS.
  • Further large-scale studies are needed to confirm generalizability across progressive MS subtypes.
Keywords:
Choroid plexusChronic inflammationEBVProgressive MS

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