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Updated: Jun 10, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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Therapy concepts in type 1 diabetes mellitus treatment: disease modifying versus curative approaches

Sigurd Lenzen1,2, Anne Jörns3

  • 1Institute of Experimental Diabetes Research, Hannover Medical School, 30625, Hannover, Germany. lenzen.sigurd@mh-hannover.de.

Journal of Molecular Medicine (Berlin, Germany)
|October 17, 2024
PubMed

Insights

Curative therapies for autoimmune diabetes require combining treatments to regenerate pancreatic beta cells and halt immune destruction. This approach is essential for treating type 1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA).

Area of Science:

  • Immunology
  • Endocrinology
  • Pharmacotherapy

Background:

  • Autoimmune diseases, such as type 1 diabetes mellitus (T1DM), are often managed with pharmacotherapy to slow disease progression.
  • Current treatments aim to manage symptoms but not achieve a cure by restoring organ function.
  • The ideal outcome for T1DM involves a pancreas with preserved beta cells and no immune cell infiltration.

Purpose of the Study:

  • To explore the potential of antibody combination therapy for autoimmune diabetes.
  • To identify requirements for curative therapies in T1DM and latent autoimmune diabetes in adults (LADA).
  • To move beyond monotherapies towards treatments with curative potential.

Main Methods:

  • Review of recent research on antibody combination therapy for autoimmune diabetes.
  • Consideration of therapeutic requirements for achieving organ regeneration and immune tolerance.
  • Analysis of strategies for preserving pancreatic beta cells.

Main Results:

  • Antibody combination therapy shows promise for autoimmune diabetes with curative potential.
  • Monotherapies are insufficient to achieve the goal of curative treatment.
  • Successful therapy requires addressing both beta cell destruction and immune infiltration.

Conclusions:

  • Combination antibody therapy represents a significant advancement towards curative treatments for autoimmune diabetes.
  • Achieving a cure necessitates a comprehensive approach targeting immune mechanisms and promoting beta cell regeneration.
  • Further research is needed to define the specific requirements for implementing effective combination therapies for T1DM and LADA patients.
Keywords:
Autoimmune diseasesDisease modifying and curative therapiesLatent autoimmune diabetes in adultsType 1 diabetes mellitus

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