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Updated: Jun 10, 2025

Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes
Published on: April 5, 2024
Quantitative Evaluation of Human Lens and Lens Capsule Elasticity by Optical Coherence Elastography Based on a
Gang Shi1,2, Yubao Zhang2, Yidi Wang2
1School of Mathematics and Physics, University of Science and Technology Beijing, Beijing, China.
Abstract:
Evaluating the biomechanical properties of the lens and lens capsule is important for the clinical diagnosis and treatment of age-related cataracts and presbyopia. In this study, we developed an optical coherent elastography technique to assess the elasticity of the lens and lens capsule in the human eye. With age, the mean Young's modulus of the lens increased from 12.28 ± 0.87 kPa to 18.59 ± 1.45 kPa, and the lens capsule increased from 6.33 ± 0.36 kPa to 13.33 ± 0.74 kPa. The results showed that the Young's modulus of the lens capsule and lens increased with age, with the Young's modulus of the lens significantly higher than that of the lens capsule. This study reports the assessment of the elasticity of the human lens and lens capsule by the OCE technique, indicating that it may provide a potential clinical tool for advancing research on diseases affecting the lens.
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