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The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case-control

Saeed Vaheb1, Mohammad Yazdan Panah2, Alireza Afshari-Safavi3

  • 1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

European Journal of Medical Research
|October 18, 2024
PubMed
Abstract

Insights

Parental consanguinity (PC) and familial multiple sclerosis (FMS) significantly increase the risk of developing MS. These genetic factors, alongside others, warrant consideration in MS risk assessment and future research.

Area of Science:

  • Neurology
  • Genetics
  • Epidemiology

Background:

  • Genetic factors like parental consanguinity (PC) and familial multiple sclerosis (FMS) are implicated in multiple sclerosis (MS) risk.
  • Investigating PC and FMS prevalence in Iranian MS patients is crucial for understanding genetic predispositions.

Purpose of the Study:

  • To determine the prevalence of parental consanguinity (PC) and familial multiple sclerosis (FMS) among people with MS (pwMS) in Isfahan, Iran.
  • To assess the association between PC, FMS, and the risk of developing MS.

Main Methods:

  • A case-control study involving 4264 pwMS and 400 healthy controls (HCs) from Isfahan, Iran.
  • Data collection included demographic, clinical characteristics, and family history of PC and FMS.
  • Multinomial logistic regression analysis was used to evaluate the relationship between PC, FMS, and MS risk.

Main Results:

  • The prevalence of PC was 29.3% and FMS was 24% among pwMS.
  • Adjusted analysis revealed a significant association between PC and MS risk (OR=3.03, 95% CI 2.23-4.13).
  • A history of FMS was also significantly associated with increased MS risk (OR=5.42, 95% CI 3.51-8.38).

Conclusions:

  • Parental consanguinity (PC) and familial multiple sclerosis (FMS) are significant risk factors for developing MS.
  • These genetic factors should be considered in comprehensive MS risk assessments.
  • Further research is needed to fully elucidate the role of these factors in MS etiology.
Keywords:
Familial multiple sclerosisMultiple sclerosisParental consanguinity

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