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Relationship between Polygenic Risk Score and the Hypnotics in Bipolar I Disorder
Hyeon Woo Lee1, Bun-Hee Lee2, Tatyana Shekhtman3
1Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Summary
Genetic susceptibility to bipolar disorder (BD) is linked to hypnotic use. This suggests sleep disturbances in BD may have a genetic basis, warranting further research into genetic overlaps.
Area of Science:
- Psychiatry
- Genetics
- Pharmacology
Background:
- Bipolar disorder (BD) significantly impacts mood, energy, and sleep, diminishing quality of life.
- Sleep disturbances are a common and debilitating feature of BD.
Purpose of the Study:
- To investigate the association between Bipolar I Disorder (BD-I) polygenic risk scores (PRS) and hypnotic use in BD-I patients.
- To explore the potential genetic underpinnings of sleep disturbances in BD.
Main Methods:
- Analysis of large-scale genome-wide association study data from the Bipolar Genomic Study.
- Categorization of 1,394 BD-I patients into hypnotic users and non-users.
- Assessment of clinical manifestations and function using the Diagnostic Interview for Genetic Studies (DIGS) score.
Main Results:
- 40% of participants (556/1,394) used hypnotics, primarily benzodiazepines.
- Higher DIGS scores and BD-polygenic risk scores (BD-PRS) were observed in the hypnotic user group.
- Logistic regression confirmed a significant association between BD-PRS and hypnotic use.
Conclusions:
- Findings suggest a link between hypnotic use and genetic susceptibility to BD.
- Prescription of hypnotics supports the hypothesis that sleep disturbances in BD-I may be genetically influenced.
- Further research is needed on genetic overlaps between BD, specific phenotypes, and medication responses.
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