NIR-II Fluorescent Nanotheranostics with a Switchable Irradiation Mode for Immunogenic Sonodynamic Therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Current nanotheranostics face challenges like complex structures and limited targeting.
• Existing systems often rely on single therapeutic modalities, hindering comprehensive treatment.

Purpose of the Study:

• To develop an integrated nanotheranostic system, NP^RBOXA, for precise tumor treatment.
• To overcome limitations of current nanotheranostics by enabling multi-modal therapy and real-time imaging guidance.

Main Methods:

• NP^RBOXA functionalized with cRGD for targeted delivery to α_vβ₃/α_vβ₅ receptors.
• Sequential irradiation modes: 808 nm laser for NIR-II fluorescence imaging and ultrasound for therapy.
• Ultrasound-induced reactive oxygen species generation for OXA-IV to OXA-II conversion, triggering immunogenic cell death.

Main Results:

• NP^RBOXA demonstrated targeted delivery and real-time imaging for optimal treatment window determination.
• Sequential irradiation successfully activated combined sonodynamic therapy, chemotherapy, and immunotherapy.
• The system facilitated immunogenic cell death in tumor cells.

Conclusions:

• NP^RBOXA offers a versatile platform for integrated theranostic applications in oncology.
• This approach enhances therapeutic efficacy and provides real-time imaging guidance for precision medicine.
• The nanotheranostic system shows promise for advancing tumor treatment strategies.