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Updated: Jun 10, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

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Prevalence, Clinical Manifestations, and Adverse Outcomes of Left Ventricular Noncompaction in Adults: A Systematic

Jordan Llerena-Velastegui1,2, Almendra Lopez-Usina1, Camila Mantilla-Cisneros1

  • 1Medical School, Pontifical Catholic University of Ecuador, Quito, Ecuador.

Cardiology Research
|October 18, 2024
PubMed

Insights

Left ventricular noncompaction (LVNC) affects 0.5% of adults, with cardiac MRI being superior for diagnosis. Key predictors of adverse outcomes include advanced NYHA class and reduced ejection fraction, guiding tailored treatments.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Internal Medicine

Background:

  • Left ventricular noncompaction (LVNC) is a cardiomyopathy with diverse clinical presentations.
  • Diagnosis and management of LVNC in adults present significant challenges.
  • Existing data on LVNC prevalence, diagnosis, and treatment efficacy require synthesis.

Purpose of the Study:

  • To synthesize current data on the prevalence of adult LVNC.
  • To evaluate diagnostic methods, focusing on imaging modalities.
  • To assess clinical outcomes and treatment efficacy for LVNC patients.

Main Methods:

  • Systematic review and meta-analysis of studies from 2000 to March 2024.
  • Inclusion of studies on adult LVNC diagnosis and management.
  • Analysis of prevalence, diagnostic accuracy, clinical manifestations, and treatment impact.

Main Results:

  • LVNC prevalence was found to be 0.5% in the adult population.
  • Cardiovascular magnetic resonance showed higher diagnostic accuracy (1.3% detection rate) than echocardiography.
  • Mortality and heart transplantation rates were 12% and 7%, respectively. NYHA class, ventricular tachycardia, and reduced LVEF predicted adverse outcomes.

Conclusions:

  • Cardiovascular magnetic resonance is superior for LVNC diagnosis.
  • Identifying predictors of adverse outcomes allows for tailored therapeutic strategies.
  • A multidisciplinary approach is crucial for improving patient outcomes in LVNC.
Abstract

Keywords:
Cardiovascular magnetic resonanceClinical outcomesDiagnostic criteriaLeft ventricular noncompactionTreatment strategies

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