Trends and Prospects of Low-Density Lipoprotein Cholesterol in Stroke: A Bibliometric Analysis

Management of low-density lipoprotein cholesterol (LDL-C) in stroke is a crucial component of cardiovascular disease care. Recent years have seen substantial progress in understanding and managing LDL-C in the context of stroke. This study utilized bibliometric methods to analyze and synthesize trends in this area over the past decade, incorporating 2,841 publications from the Web of Science database. The analyses included trend topic analysis, co-authorship analysis, and co-citation analysis. The findings indicate that research had predominantly concentrated on epidemiological studies related to pharmacological management strategies. Future research is expected to continue exploring lipid-lowering therapies, including both established treatments like statins and newer drugs such as proprotein convertase subtilisin-kexin type 9 inhibitors. Assessing residual cholesterol and employing Mendelian randomization techniques may become potential research hotspots. The New England Journal of Medicine is the most globally influential journal, while Circulation holds the most influence within the field, and Atherosclerosis ranks as the most prolific. International collaboration in this research area was strong between the USA and England, followed by the USA and China. However, collaboration between productive institutions in the USA and China remains limited, highlighting the need to strengthen partnerships between these institutions to further advance the field.