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Impact of Replacing Sedentary Behavior with Physical Activity and Sleep on Stroke Risk: A Prospective Cohort Study
Xiao-Fang Dong1, Qiang Zhang2, Jia-Ning Wei2
1Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Nature and Science of Sleep
|October 18, 2024
Summary
Reducing sedentary behavior (SB) and improving sleep are key to lowering stroke risk. Replacing leisure-time SB with physical activity or sleep significantly decreases stroke incidence, especially for those with unhealthy sleep patterns.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Sedentary behavior (SB) is increasingly recognized as a significant public health concern.
- Understanding the relationship between leisure-time SB, sleep, and stroke risk is crucial for preventative strategies.
Purpose of the Study:
- To investigate the correlation between leisure-time sedentary behavior (SB) and stroke risk.
- To analyze the impact of substituting SB with light physical activity (LPA), moderate physical activity (MPA), vigorous physical activity (VPA), or sleep on stroke risk using the isotemporal substitution model (ISM).
Main Methods:
- Utilized data from 478,198 participants in the UK Biobank.
- Collected leisure-time SB and physical activity (PA) data via a standardized questionnaire.
- Employed Cox proportional hazards and isotemporal substitution models (ISM) for analysis.
Main Results:
- Identified 10,003 incident stroke cases over 12.7 years.
- Increased stroke risk was observed with prolonged leisure-time SB (HRs ranging from 1.06 to 1.24 for >4 hours/day).
- Substituting leisure-time SB with LPA, VPA, or sleep demonstrated significant stroke risk reduction (up to 22.0% for sleep substitution in individuals sleeping ≤8h/day).
Conclusions:
- Leisure-time SB and unhealthy sleep durations are confirmed stroke risk factors.
- Substituting SB with adequate sleep or VPA is an effective stroke risk reduction strategy, particularly for individuals with specific sleep durations.
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