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Combining two injectable progesterone formulas for estrous synchronization in ewes.

Milena Luzorio Simões1, Felipe Zandonadi Brandão1, Juliana Dantas Rodrigues Santos1

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Summary

Injectable progesterone (iP4) effectively synchronizes estrous in ewes, matching traditional devices. Adding GnRH improves luteal quality, enhancing reproductive management potential in sheep.

Keywords:
follicle dynamicsreproductive efficiencyreproductive seasonalitysheep

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Area of Science:

  • Veterinary Science
  • Reproductive Biology
  • Animal Science

Background:

  • Estrous synchronization is crucial for efficient sheep breeding programs.
  • Traditional progesterone synchronization methods include intravaginal devices.
  • Novel injectable progesterone (iP4) formulations offer alternative approaches.

Purpose of the Study:

  • To evaluate the efficacy of combined long-acting and short-acting injectable progesterone (iP4) for estrous synchronization in ewes.
  • To compare the effectiveness of iP4 with traditional intravaginal progesterone devices.
  • To determine if gonadotropin-releasing hormone (GnRH) administration improves reproductive outcomes with iP4 treatment.

Main Methods:

  • Two experiments were conducted involving Santa Inês and Corriedale ewes.
  • Ewes were treated with intravaginal devices or combined iP4 formulations.
  • Some ewes received GnRH concurrently with iP4 to assess its impact.
  • Reproductive parameters including estrous, ovulation, follicular dynamics, and progesterone levels were monitored.

Main Results:

  • Combined iP4 effectively induced an artificial luteal phase and synchronized estrous in ewes.
  • iP4 showed comparable efficacy to traditional intravaginal progesterone devices.
  • The inclusion of GnRH with iP4 treatment enhanced corpus luteum quality, evidenced by increased diameter and vascularization.
  • A trend towards more synchronized ovulation was observed with iP4 treatment in the first experiment.

Conclusions:

  • Combined injectable progesterone (iP4) is an effective alternative for estrous synchronization in ewes.
  • GnRH supplementation improves luteal function, potentially benefiting sheep reproductive management.
  • Further field studies are warranted to assess the fertility outcomes of these protocols.