Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

151
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
151
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

179
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
179
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

203
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
203
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

1.9K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcollumelar Incision and Closure.

Facial plastic surgery & aesthetic medicine·2025
Same author

Night-time neuronal activation of Cluster N in a North American songbird.

PloS one·2024
Same author

Gene regulation and speciation in a migratory divide between songbirds.

Nature communications·2024
Same author

Secondary Hemochromatosis Leading to Acute Coronary Syndrome in a Thalassemic Patient.

Cureus·2023
Same author

Assessment of medication adherence among Lebanese adult patients with non-communicable diseases during COVID-19 lockdown: a cross-sectional study.

Frontiers in public health·2023
Same author

Spatial modulation of hippocampal activity in freely moving macaques.

Neuron·2021

Related Experiment Video

Updated: Jun 10, 2025

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
13:25

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

5.6K

Cisplatin vestibulotoxicity: a current review.

Tamara Fleihan1, Marc Elie Nader2, J David Dickman1

  • 1Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States.

Frontiers in Surgery
|October 18, 2024
PubMed
Summary

Cisplatin chemotherapy can damage the inner ear's balance system (vestibulotoxicity), affecting vestibular hair cells. Research explores its mechanisms and protective strategies to improve cancer patient quality of life.

Keywords:
cisplatinneurotologyoncologyototoxicityvestibular

More Related Videos

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.4K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.4K

Related Experiment Videos

Last Updated: Jun 10, 2025

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
13:25

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

5.6K
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.4K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.4K

Area of Science:

  • Ototoxicology
  • Neuroscience
  • Oncology

Background:

  • Cisplatin is a vital chemotherapy agent with known ototoxicity affecting cochlear hair cells.
  • The impact of cisplatin on the vestibular system (balance organ) is less understood.
  • Vestibulotoxicity is a significant chemotherapy complication impacting patient quality of life.

Purpose of the Study:

  • To comprehensively review existing literature on cisplatin-induced vestibulotoxicity.
  • To elucidate the mechanisms underlying cisplatin's damage to the vestibular system.
  • To identify potential protective agents and discuss diagnostic challenges.

Main Methods:

  • Literature review of animal and human studies on cisplatin and the vestibular system.
  • Analysis of mechanisms including apoptosis, oxidative stress, and inflammatory cytokines.
  • Evaluation of preclinical findings on protective agents and clinical observations of dysfunction.

Main Results:

  • Animal studies show dose-dependent vestibular hair cell loss, primarily affecting utricular cells.
  • Mechanisms involve apoptosis, oxidative stress, and inflammatory cytokines.
  • Human studies report vestibular dysfunction symptoms like dizziness and vertigo.

Conclusions:

  • Cisplatin-induced vestibulotoxicity is a significant clinical issue.
  • Further research is needed to understand mechanisms and improve diagnosis and management.
  • Enhancing quality of life for cancer patients requires addressing chemotherapy-induced vestibular damage.