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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Advances in targeting tumor microenvironment for immunotherapy.

Lugang Wang1,2, Liubo Zhang1, Zhen Zhang1

  • 1Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

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|October 18, 2024
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The tumor microenvironment (TME) suppresses immune responses, hindering cancer therapies. Targeting and remodeling the TME can enhance the host immune system to fight tumors effectively.

Keywords:
cancerimmunosuppressionimmunotherapytargetedtumor microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • The tumor microenvironment (TME) is crucial for cancer progression, invasion, and metastasis.
  • The TME exhibits immunosuppressive characteristics, including hypoxia, acidity, high interstitial pressure, and vascular permeability.
  • These factors contribute to immune evasion and reduced immunotherapy efficacy.

Purpose of the Study:

  • To detail the characteristics and composition of the TME.
  • To explain how the TME impairs immune surveillance.
  • To summarize therapeutic strategies for TME regulation.

Main Methods:

  • Literature review of TME characteristics.
  • Analysis of immunosuppressive components within the TME.
  • Synthesis of targeted therapeutic approaches for TME modulation.

Main Results:

  • The TME possesses multiple immunosuppressive features that promote cancer growth.
  • These features create a barrier against effective anti-tumor immune responses.
  • Targeting the TME is a promising strategy to improve cancer immunotherapy.

Conclusions:

  • Understanding TME composition and function is key to developing new cancer treatments.
  • TME remodeling can overcome immune evasion and enhance immunotherapy outcomes.
  • Targeted TME regulation offers a viable approach to boost anti-tumor immunity.