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A Framework for Interpretability in Machine Learning for Medical Imaging.

Alan Q Wang1,2, Batuhan K Karaman1,2, Heejong Kim2

  • 1School of Electrical and Computer Engineering, Cornell University-Cornell Tech, New York City, NY 10044, USA.

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Summary
This summary is machine-generated.

Interpretability in machine learning for medical imaging (MLMI) needs formalization. This study defines five core elements and a framework to guide MLMI model design and application for better real-world use.

Keywords:
Interpretabilityexplainabilitymachine learningmedical imaging

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Area of Science:

  • Medical Imaging
  • Machine Learning
  • Artificial Intelligence in Healthcare

Background:

  • Interpretability in machine learning for medical imaging (MLMI) is crucial but lacks clear definition.
  • Existing approaches often lack a structured understanding of interpretability's goals and components.

Purpose of the Study:

  • To formalize the goals and elements of interpretability specifically within the MLMI context.
  • To develop a framework that guides the design and application of interpretable MLMI models.

Main Methods:

  • Reasoning about real-world medical image analysis tasks and machine learning intersections.
  • Identifying and defining five core elements of MLMI interpretability: localization, visual recognizability, physical attribution, model transparency, and actionability.

Main Results:

  • A formalized framework for MLMI interpretability, outlining a step-by-step approach.
  • Identification of five key elements crucial for practical MLMI interpretability.

Conclusions:

  • The proposed framework clarifies MLMI-specific interpretability goals and considerations.
  • This work aims to guide practitioners and researchers in developing and utilizing more interpretable MLMI models for improved clinical impact.