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Association between ulcerative colitis and acute appendicitis - A Mendelian randomization study

Sangsang Chen1, Zhebin Dong2, Hanting Xiang2

  • 1Gastrointestinal Surgery, The Afffliated Lihuili Hospital, Ningbo University, .

Revista Espanola De Enfermedades Digestivas
|October 18, 2024
PubMed

Insights

This study investigated the link between ulcerative colitis (UC) and appendicitis. Findings suggest a genetic predisposition to UC may decrease the risk of developing acute appendicitis.

Area of Science:

  • Gastroenterology
  • Genetics
  • Epidemiology

Background:

  • The exact cause of ulcerative colitis (UC) remains unknown.
  • Some research suggests the appendix might be an initial site for UC development.
  • Patients with UC often exhibit a high incidence of appendicitis.

Purpose of the Study:

  • To investigate a potential causal relationship between ulcerative colitis and acute appendicitis using Mendelian randomization (MR).

Main Methods:

  • Utilized Mendelian randomization (MR) analysis.
  • Examined genetic liability associated with UC and its effect on acute appendicitis risk.

Main Results:

  • A significant association was found between the genetic liability of UC and a reduced risk of acute appendicitis (OR, 0.9362; 95% CI 0.9014 - 0.9723; p = 0.00064).

Conclusions:

  • Genetic factors contributing to ulcerative colitis appear to lower the risk of acute appendicitis.
  • Further research is required to confirm these findings and elucidate the underlying mechanisms.

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