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Aging affects the mouse brain in a region-specific manner.

Ling Cai1,2, Yueman Zhang1,2, Yuxi Zhou1,2

  • 1Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|October 18, 2024
PubMed
Summary
This summary is machine-generated.

Glial aging accelerates in white matter, impacting cognitive decline. Dietary restriction and young plasma show potential to reverse these age-related changes, offering new therapeutic avenues.

Keywords:
Agingbrain regioncognitive declinemicrogliawhite matter

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Area of Science:

  • Neuroscience
  • Aging Research
  • Cellular Biology

Background:

  • Global population aging presents challenges, including age-related cognitive decline.
  • Understanding the mechanisms of brain aging is crucial for developing interventions.

Purpose of the Study:

  • To investigate region-specific glial aging in the brain.
  • To explore interventions that could reverse age-related changes in glial cells and gene expression.

Main Methods:

  • Comparative analysis of glial aging in white matter versus cortical regions.
  • Examination of gene expression patterns in specialized neuronal populations.
  • Assessment of the effects of dietary restriction and young mouse plasma on glial cells.

Main Results:

  • Glial aging is significantly accelerated in white matter compared to cortical regions.
  • Region-specific changes in gene expression were observed in specialized neuronal populations.
  • Dietary restriction reprogrammed circadian clock genes in glial cells.
  • Young mouse plasma reversed age-related gene expression patterns in glial cells.

Conclusions:

  • Brain aging is region-specific, with white matter aging more rapidly.
  • Interventions like dietary restriction and young plasma can modulate glial aging and gene expression.
  • These findings open new avenues for treating age-related cognitive impairments.