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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Flavonoids as modulators of metabolic reprogramming in renal cell carcinoma (Review)

Asif Shahzad1, Wenjing Liu1, Yijian Sun1

  • 1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.

Oncology Reports
|October 18, 2024
PubMed

Insights

Flavonoids offer a novel approach to treating renal cell carcinoma (RCC) by targeting its metabolic reprogramming. This review explores how these natural compounds can combat cancer by influencing multiple metabolic pathways in RCC tumors.

Area of Science:

  • Oncology
  • Biochemistry
  • Pharmacology

Background:

  • Renal cell carcinoma (RCC) exhibits significant metabolic reprogramming due to genetic mutations.
  • Tumors adapt nutrient metabolism to support cancer cell growth and survival.
  • Current therapies often fail to address this metabolic adaptability.

Purpose of the Study:

  • To review the metabolic reprogramming in RCC.
  • To explore the potential of flavonoids as anticancer agents targeting RCC metabolism.
  • To understand the anticancer mechanisms of flavonoids in RCC.

Main Methods:

  • Comprehensive literature review of metabolic reprogramming in RCC.
  • Analysis of flavonoid properties and their impact on cellular metabolism.
  • Examination of existing research on flavonoids and cancer treatment.

Main Results:

  • RCC metabolism is characterized by altered glycolysis, oxidative phosphorylation, and fatty acid synthesis.
  • Flavonoids possess antioxidant and anti-inflammatory properties that can modulate multiple metabolic targets.
  • Flavonoids show promise in targeting the adaptability of RCC metabolic pathways.

Conclusions:

  • Flavonoids represent a promising natural product class for developing novel RCC therapies.
  • Targeting metabolic reprogramming in RCC with flavonoids may offer a new therapeutic strategy.
  • Further research into flavonoid mechanisms could lead to new natural antitumor drugs for RCC.
Keywords:
RCCWarburg effectanticancer drugflavonoidsmetabolic reprogramming

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