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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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Diagnostic approach to leukemia cutis : A differential diagnostic step-by-step algorithm.

Alex Jenei1, Alexandar Tzankov2

  • 1Department of Pathology and Experimental Cancer Research Semmelweis University, Faculty of Medicine, Budapest, Hungary.

American Journal of Clinical Pathology
|October 18, 2024
PubMed
Summary

Leukemia cutis, a term for skin infiltrates, presents diagnostic challenges. This review clarifies confusion and offers a stepwise approach using advanced markers for accurate diagnosis of cutaneous myeloid and lymphoid neoplasms.

Keywords:
cutaneous lymphomaextramedullary myeloid proliferationleukemia cutismyelodysplasia cutismyeloid sarcomasmall blue round cell tumor

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Area of Science:

  • Dermatopathology
  • Hematopathology
  • Oncology

Background:

  • Leukemia cutis is a complex term for neoplastic hematopoietic infiltrates in the skin.
  • Cutaneous myeloid or lymphoid proliferations pose significant diagnostic challenges for pathologists.

Purpose of the Study:

  • To clarify the confusion surrounding the term leukemia cutis.
  • To detail common differential diagnoses for cutaneous myeloid and lymphoid neoplasms.
  • To propose a diagnostic strategy for challenging skin lesions.

Main Methods:

  • Literature review synthesizing current knowledge.
  • Incorporation of authors' clinical experience.
  • Focus on differential diagnoses in daily practice.

Main Results:

  • Addresses precursor and mature myeloid/lymphoid neoplasms.
  • Includes recently described mature extramedullary myeloid proliferations.
  • Suggests a stepwise diagnostic approach.

Conclusions:

  • Accurate diagnosis of challenging skin lesions is achievable.
  • A combination of ancillary techniques is crucial for precise diagnosis.