Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

1
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
1
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.7K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Effect of moxibustion on serum inflammatory response in rat models of rheumatoid arthritis based on GSDMD].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2026
Same author

Qufeng xuanbi formula attenuates HDM-induced allergic asthma by targeting the STING/HIF-1α/glycolysis axis.

Journal of ethnopharmacology·2026
Same author

Reduced EphB2 Expression Due to Hypermethylation in DLBCL-NOS Is Associated with Prognosis.

The Tohoku journal of experimental medicine·2026
Same author

Irrigation fluid temperature modulates coagulation and endothelial biomarkers in patients undergoing TURP.

Journal of medical biochemistry·2026
Same author

Identification and experimental validation of autophagy-related genes in focal segmental glomerulosclerosis by integrating bioinformatics and machine learning.

Scientific reports·2025
Same author

Respiratory sarcopenia as a mortality predictor for chronic kidney disease: a dual-cohort longitudinal study.

Renal failure·2025

Related Experiment Video

Updated: Jun 10, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.4K

Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell

Yi Zhang1, Tianwen Yao1, Yanqiu Xu1

  • 1Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Renal Failure
|October 18, 2024
PubMed
Summary

Increased Rac1 (RAC1) expression is linked to a higher risk of steroid-sensitive nephrotic syndrome (SSNS). Targeting RAC1 may offer a new therapeutic approach for SSNS patients.

Keywords:
Mendelian randomizationRAC1podocytesingle-cell RNA-sequencing, proteomic analysissteroid-sensitive nephrotic syndrome

More Related Videos

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

12.9K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.8K

Related Experiment Videos

Last Updated: Jun 10, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.4K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

12.9K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.8K

Area of Science:

  • Nephrology
  • Genetics
  • Molecular Biology

Background:

  • The small GTPase Rac1 (RAC1) is implicated in podocyte disorders and steroid-sensitive nephrotic syndrome (SSNS).
  • Understanding the causal relationship between circulating RAC1 and SSNS is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate and validate the potential causal association between circulating RAC1 and SSNS.
  • To explore RAC1's role in the pathogenesis of SSNS at both gene expression and protein levels.

Main Methods:

  • Mendelian randomization analysis was employed to assess the causal association between RAC1 and SSNS.
  • Validation included single-cell RNA-sequencing, proteomic analysis, and a puromycin aminonucleoside (PAN)-induced nephrosis model.

Main Results:

  • Elevated RAC1 expression, at both gene and protein levels, was significantly associated with an increased risk of SSNS.
  • Single-cell RNA-sequencing and proteomic analyses confirmed higher RAC1 expression in SSNS patients.
  • Experimental models further supported the association between increased RAC1 expression and nephropathy.

Conclusions:

  • Increased RAC1 expression may be causally linked to SSNS.
  • Targeting RAC1 presents a potential therapeutic strategy for managing SSNS.