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Related Experiment Videos

Radioiodide transfer across sheep placenta.

J F Canning, T E Stacey, R H Ward

    The American Journal of Physiology
    |January 1, 1986
    PubMed
    Summary

    This study reveals that radioiodide transport across the placenta in sheep is not purely passive. Active transport mechanisms, inhibitable by iodide, are involved in regulating iodide transfer between mother and fetus.

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    Area of Science:

    • Reproductive physiology
    • Maternal-fetal medicine
    • Nuclear medicine

    Background:

    • Understanding transplacental transport is crucial for fetal health and managing radiopharmaceutical use during pregnancy.
    • Radioiodide is a common radioisotope used in medical imaging and therapy, necessitating knowledge of its placental transfer.

    Purpose of the Study:

    • To quantify unidirectional transplacental clearances of radioiodide in a sheep model.
    • To investigate the mechanisms governing radioiodide transfer across the placenta, including passive and active transport.
    • To assess the influence of potential difference and iodide concentration on radioiodide clearance.

    Main Methods:

    • Utilized 33 catheterized conscious sheep for in vivo experiments.
    • Calculated net radioiodide fluxes following injection into fetal and/or maternal circulations.
    • Measured maternofetal potential difference (PD) and performed bidirectional clearance ratio analyses.
    • Administered thiocyanate or iodide to assess their impact on radioiodide clearance.

    Main Results:

    • Radioiodide clearance reached a steady state within 20 minutes post-injection.
    • Fetomaternal clearance was correlated with the measured maternofetal potential difference.
    • Bidirectional clearance ratios deviated significantly from predictions based on passive flux and PD, suggesting active transport.
    • Thiocyanate and iodide injections reduced radioiodide clearance, with a notable decrease observed at elevated fetal plasma iodide concentrations.

    Conclusions:

    • Transplacental radioiodide transport in sheep involves an active, inhibitable iodide-transporting system.
    • The findings challenge purely passive diffusion models for iodide transfer across the placenta.
    • This active transport mechanism plays a significant role in regulating iodide flux between the maternal and fetal circulations.

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