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Updated: Jun 10, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Coping style and psychopathological morbidity in patients with advanced melanoma: differences between cancer therapy,
Bernardo Carli1, Raffaella Grifoni2, Elisabetta Surrenti3
1SOSD Psycho-oncology, USL Toscana Centro, Florence, Italy - dr.bernardocarli@gmail.com.
Background:
The incidence of melanoma has been steadily increasing in recent years and remains one of the most frequent cancers in adolescents and young adults. The literature shows how a high percentage of melanoma patients present with high anxiety and depression scores and a correlation between worsening quality of life and impaired body image has been shown. The present study aimed to investigate the relationship between cutaneous and visceral metastasis in a group of 73 patients with advanced melanoma in relation to body image, anxiety, depression, and coping style.
Methods:
Hospital Anxiety and Depression Scale, Body Image Scale and Mini-Mac questionnaires were administered to a sample of 73 subjects with advanced melanoma (stage III and IV); Analyses were performed with SPSS version 28.01 and a P value <0.05 was considered significant.
Results:
Emerging results indicated greater body image impairment in patients with skin metastasis, no significant difference in anxiety and depression by staging. Patients receiving target therapy showed a reduction in anxiety and depression compared with patients receiving immunotherapy.
Conclusions:
In line with the literature, cutaneous metastatic involvement negatively affected body image, a prevalence rate of anxiety and depression of 28,8% and 19.2%, respectively, emerged in the sample, while 17.8% reported significant body image impairment, suggesting how melanoma impacts in patient's quality of life.
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