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Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

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Related Experiment Video

Updated: Jun 10, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Proteins-Based Nanoparticles for Benznidazole Enteric Delivery.

Victor A Pilicita¹, Ana S Sonzogni^1,2, Mariana Allasia¹

¹Polymer Reaction Engineering Group, INTEC (Universidad Nacional del Litoral-CONICET), Güemes 3450, Santa Fe, 3000, Argentina.

Macromolecular Bioscience

|October 18, 2024

Summary

New nanoparticles improve benznidazole delivery for Chagas disease treatment. This approach targets drug release in the small intestine, potentially reducing side effects and enhancing therapeutic outcomes for this widespread parasitic infection.

Keywords:

benznidazole chagas disease eudragit L100‐55® coating oral release zein‐casein bioparticle

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Area of Science:

Biomaterials Science
Pharmaceutical Sciences
Parasitology

Background:

Chagas disease, caused by Trypanosoma cruzi, affects millions globally, with limited therapeutic options.
Current treatments like benznidazole have adverse effects linked to administration challenges.
Nanoparticle drug delivery systems offer a strategy to improve targeted delivery and reduce side effects.

Purpose of the Study:

To develop and characterize zein-casein-based nanoparticles (Bioparticles, BP) coated with Eudragit L100-55 (BP:EU).
To evaluate the potential of BP:EU for enteric delivery of benznidazole for Chagas disease treatment.
To assess the pH-responsive drug release characteristics of the developed nanoparticles.

Main Methods:

Synthesis of zein-casein-based nanoparticles (BP) and subsequent coating with Eudragit L100-55 (BP:EU).
Characterization of BP:EU nanoparticles to confirm structure and properties.
Evaluation of pH-responsive drug release profiles to assess enteric delivery potential.

Main Results:

Successful synthesis of BP:EU nanoparticles was confirmed through physical characterization.
The BP:EU nanoparticles demonstrated pH-responsive behavior, indicating controlled release.
The formulation is designed to minimize premature benznidazole release in the stomach and promote release in the small intestine.

Conclusions:

Zein-casein-based nanoparticles coated with Eudragit L100-55 represent a promising approach for enteric benznidazole delivery.
This novel delivery system addresses challenges in benznidazole administration for Chagas disease.
The developed nanoparticles have the potential to improve therapeutic responses and minimize adverse effects in Chagas disease treatment.