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Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Improved ADHD Diagnosis Using EEG Connectivity and Deep Learning through Combining Pearson Correlation Coefficient

Elham Ahmadi Moghadam1, Farhad Abedinzadeh Torghabeh1, Seyyed Abed Hosseini2

  • 1Department of Biomedical Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Neuroinformatics
|October 18, 2024
PubMed
Summary
This summary is machine-generated.

This study presents a novel method for diagnosing Attention Deficit Hyperactivity Disorder (ADHD) using fused brain connectivity maps and an attention-based convolutional neural network (Att-CNN). The approach achieved high accuracy, offering a promising tool for early ADHD detection.

Keywords:
ADHD DiagnosisAttention-Based CNNBrain ConnectivityEEGPearson Correlation CoefficientPhase-Locking Value

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Medical Imaging

Background:

  • Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurobehavioral disorder in children and adolescents.
  • Early detection of ADHD is crucial for effective treatment and improved patient outcomes.
  • Electroencephalogram (EEG) connectivity analysis offers insights into brain network patterns relevant to ADHD diagnosis.

Purpose of the Study:

  • To develop and evaluate a novel ADHD diagnostic method integrating linear and nonlinear EEG connectivity.
  • To assess the efficacy of an attention-based convolutional neural network (Att-CNN) for ADHD classification.
  • To optimize the diagnostic performance by evaluating different optimizers and learning rates.

Main Methods:

  • EEG data from individuals with and without ADHD were analyzed.
  • Linear (Pearson Correlation Coefficient - PCC) and nonlinear (Phase-Locking Value - PLV) connectivity measures were computed.
  • Fused Connectivity Maps (FCMs) were created from various EEG frequency subbands.
  • An attention-based convolutional neural network (Att-CNN) was employed for classification.
  • The performance was evaluated using different optimizers (Adam, SGD) and learning rates.

Main Results:

  • The proposed model achieved high diagnostic performance, with accuracy, precision, recall, and F1 Score reaching 98.88%, 98.41%, 98.19%, and 98.30%, respectively.
  • Optimal performance was observed using the SGD optimizer with a learning rate of 1e-1 on the theta band FCM.
  • The integration of FCM and Att-CNN demonstrated significant potential for ADHD diagnosis.

Conclusions:

  • The developed method combining FCM and Att-CNN shows high accuracy in diagnosing ADHD.
  • This technique offers a reliable approach for the early detection of ADHD, potentially improving patient outcomes.
  • The study highlights the utility of advanced machine learning techniques in analyzing complex EEG connectivity data for neurodevelopmental disorders.