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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

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Stem Cell Interventions in Neurology: From Bench to Bedside.

Miguel A Pappolla¹, Ping Wu², Xiang Fang¹

¹Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA.

Journal of Alzheimer'S Disease : JAD

|October 18, 2024

Summary

Stem cell therapies offer new treatments for neurological and aging disorders. This review covers neural and mesenchymal stem cells, their properties, and challenges in clinical translation.

Keywords:

Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis multiple sclerosis regenerative medicine stem cells stroke traumatic brain injury

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Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

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Area of Science:

Regenerative Medicine
Neuroscience
Gerontology

Background:

Stem cell therapies are emerging as a significant approach for treating neurological and age-related conditions.
Understanding the molecular and functional characteristics of stem cells is crucial for their therapeutic application.

Purpose of the Study:

To review the role of neural stem cells and mesenchymal stem cells in neurological diseases.
To explore the potential of stem cells in combating the aging process.
To discuss laboratory-modified stem cells and their implications.

Main Methods:

Literature review of stem cell properties, including self-renewal, differentiation, and paracrine effects.
Analysis of stem cell applications in stroke, multiple sclerosis, ALS, TBI, Parkinson's, and Alzheimer's disease.
Examination of induced pluripotent stem cells and transgenic stem cells.

Main Results:

Stem cells, particularly neural and mesenchymal types, show promise in treating various neurological disorders.
Challenges in translating findings from preclinical studies to human trials persist.
Modified stem cells and stem cell-derived exosomes represent future therapeutic avenues.

Conclusions:

Stem cell therapies hold significant potential for neurological and age-related diseases.
Further research is needed to overcome translational hurdles and explore novel stem cell derivatives.
A comprehensive understanding of stem cell mechanisms is key to advancing regenerative medicine.