Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

71.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.4K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

392
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
392

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thymus-expressed chemokine promotes survival of PC12 cells via PI3K pathway.

Neurochemistry international·2011
Same author

Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish.

The Journal of biological chemistry·2011
Same author

A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome.

Human molecular genetics·2011
Same author

Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.

PloS one·2011
Same author

Antibiofouling hybrid dendritic Boltorn/star PEG thiol-ene cross-linked networks.

ACS applied materials & interfaces·2011
Same author

An absolute test for axicon surfaces.

Optics letters·2011

Related Experiment Video

Updated: Jun 10, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

2.7K

Comprehensive gut microbiota composition and microbial interactions among the three age groups.

Jun Ma1,2, Xiaohua Yang3, Jianwu He3

  • 1School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, China.

Plos One
|October 18, 2024
PubMed
Summary

Gut microbiome shifts occur with aging, with specific bacteria decreasing and fungi/archaea changing. These age-related microbial signatures offer insights into longevity and gut health dynamics.

More Related Videos

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.2K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
00:06

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

6.9K

Related Experiment Videos

Last Updated: Jun 10, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

2.7K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.2K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
00:06

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

6.9K

Area of Science:

  • Microbiology
  • Gerontology
  • Bioinformatics

Background:

  • Aging is associated with significant changes in the gut microbiome.
  • Understanding these shifts is crucial for longevity research and identifying health markers.
  • Confounding factors in aging studies necessitate robust data reprocessing.

Purpose of the Study:

  • To reprocess metagenomic data from multiple aging studies to minimize batch effects.
  • To analyze gut microbiome diversity and abundance across different age cohorts (young, elderly, centenarians).
  • To identify specific microbial signatures associated with aging and their co-occurrence patterns.

Main Methods:

  • Reprocessing of metagenomic sequencing data from four aging studies.
  • Evaluation and minimization of confounding factors and batch effects.
  • Analysis of gut microbiome diversity, abundance, and co-occurrence networks using Fisher's exact test.

Main Results:

  • Four bacterial species (Ligilactobacillus ruminis, Turicibacter sp. H121, Blautia massiliensis, Anaerostipes hadrus) were depleted with age.
  • Archaea abundance decreased with age, while Candida albicans and Shuimuvirus IME207 increased in centenarians.
  • Distinct microbial signatures were identified for young, elderly, and centenarian groups, with representative species selected for further interaction analysis.

Conclusions:

  • Gut microbiome composition significantly changes across the human lifespan.
  • Specific microbial taxa are indicative of different aging stages.
  • These findings provide insights into the ecological dynamics of the gut microbiome during aging and longevity.