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Multivalent supramolecular fluorescent probes for accurate disease imaging
Qian Wu1, Zhixuan Zhou1, Li Xu1
1State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Science Advances
|October 18, 2024
Summary
New supramolecular probes improve optical imaging accuracy by evading immune system clearance. These stable, bright probes enhance disease detection and surgical navigation, advancing clinical translation.
Area of Science:
- Biomedical Engineering
- Materials Science
- Optical Imaging
Background:
- Optical imaging is crucial for disease diagnosis and treatment planning.
- Mononuclear phagocyte system (MPS) uptake limits the accuracy of current imaging agents.
- Developing imaging probes that evade MPS clearance is essential for improved in vivo applications.
Purpose of the Study:
- To create novel supramolecular probes with enhanced stability and optical properties for accurate in vivo imaging.
- To overcome limitations posed by MPS uptake in optical imaging.
- To establish a versatile platform for advanced medical imaging.
Main Methods:
- Utilizing multivalent host-guest interactions between cyanine dyes and β-cyclodextrin polymers.
- Employing a self-assembly approach to control probe size and surface properties.
- Evaluating probe stability, fluorescence efficiency, and MPS evasion in vivo.
Main Results:
- Developed supramolecular probes with enhanced stability and fluorescence efficiency.
- Achieved prolonged bloodstream circulation and evasion of MPS clearance.
- Demonstrated improved signal-to-background ratios for enhanced imaging.
- Showcased advancements in early acute kidney injury diagnosis and tumor imaging/surgical navigation.
Conclusions:
- Multivalent host-guest interactions create robust supramolecular probes for optical imaging.
- The developed probes effectively evade MPS clearance, improving in vivo imaging performance.
- This strategy offers a versatile platform for clinical translation and multiple imaging modalities.
