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BioTRY: A Comprehensive Knowledge Base for Titer, Rate, and Yield of Biosynthesis.

Yu Tian1, Liwen Yang1, Shaozhen Ding1

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Summary

Synthetic biology generates large datasets for evaluating fermentation economics. BioTRY is a new database capturing key economic indicators—titer, rate, and yield (TRY)—to aid researchers in assessing biosynthesis viability.

Keywords:
Biosynthesisratetiteryield

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Area of Science:

  • Synthetic biology
  • Biotechnology
  • Bioinformatics

Background:

  • Synthetic biology is a data-intensive field.
  • Evaluating economic viability of fermentation processes is crucial.
  • Existing bioinformatics databases lack comprehensive Titer, Rate, and Yield (TRY) data.

Purpose of the Study:

  • To develop BioTRY, a user-friendly database for TRY data.
  • To consolidate TRY data from original research publications.
  • To support economic viability assessments in biosynthesis.

Main Methods:

  • Compiled data on >5,000 biochemicals and >3,800 strains.
  • Extracted over 52,000 TRY entries with original references.
  • Developed an intuitive and accessible tool for data retrieval.

Main Results:

  • BioTRY database created with extensive TRY data.
  • Includes data on biochemicals, strains, and original references.
  • Freely available online at http://www.synbiohealth.cn/biotry.

Conclusions:

  • BioTRY is the first database of its kind for biosynthesis TRY data.
  • Aims to aid researchers and decision-makers in understanding biosynthesis.
  • Facilitates foresight into potential applications and prospects of biosynthesis.