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Development of Functionalized Polylactide Thin Films Using Poly(methylhydrogenosiloxane) Sol-Gel Process with

Jules Audourenc1, Héloïse Baldo1, Maximilien Coronas1

  • 1Institut Européen des Membranes, IEM, CNRS, ENSCM, Université de Montpellier, 34095 Montpellier, France.

Langmuir : the ACS Journal of Surfaces and Colloids
|October 18, 2024
PubMed
Summary
This summary is machine-generated.

Biobased polylactide (PLA) films were hydrophilized using a polysiloxane gel platform. This surface modification significantly improved wettability and reduced protein and bacterial adhesion, showing potential for medical applications.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Surface Chemistry

Background:

  • Biobased polylactide (PLA) is a promising material but requires surface modification for advanced applications.
  • Hydrophilization of polymer surfaces is crucial for improving biocompatibility and reducing biofouling.
  • Developing scalable platforms for surface functionalization is essential for industrial viability.

Purpose of the Study:

  • To develop a scalable method for hydrophilizing polylactide (PLA) films.
  • To graft novel hydrophilic compounds onto PLA surfaces via a polysiloxane gel platform.
  • To evaluate the impact of surface modification on wettability, biocompatibility, and antifouling properties.

Main Methods:

  • PLA films were coated with poly(methylhydrogenosiloxane) (PMHS) via sol-gel condensation.
  • Hydrophilic alkene-containing molecules (triethylene glycol monomethyl allyl and allylcarboxybetaine) were covalently grafted using hydrosilylation.
  • Surface characterization included FTIR, XPS, and AFM.
  • Wettability was assessed using water contact angle (WCA) measurements.
  • Biocompatibility and antifouling properties were evaluated through protein adsorption, bacterial adhesion, and cytotoxicity tests.

Main Results:

  • Homogeneous PMHS coating on PLA films was confirmed with low surface roughness (RMS = 0.29 nm).
  • Hydrophilization significantly reduced water contact angles from 80° (native PLA) to 38° (TEGMEA-grafted) and 42° (ACB-grafted).
  • Functionalized PLA films showed significantly reduced protein adsorption and bacterial adhesion.
  • Cytotoxicity tests confirmed that the surface modification did not compromise PLA's inherent biocompatibility.

Conclusions:

  • The polysiloxane gel serves as an effective platform for scalable surface hydrophilization of PLA films.
  • Covalent grafting of hydrophilic compounds enhances wettability and provides significant antifouling properties.
  • This surface functionalization strategy holds great potential for biomedical applications requiring biocompatible and non-fouling materials.