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Updated: Jun 10, 2025

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors
Published on: December 3, 2013
Novel genotyping definition and molecular characteristics of canine circovirus in China
Jun Ji1, Ruiqi Jiao1, Zhibin Zhang1
1Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering, and Technology Center of Health Products for Livestock and Poultry, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Nanyang Normal University, Nanyang, 473061, PR China.
Abstract:
Canine circovirus (CCV) has been detected globally, but its genotyping remains unevenly characterized. To comprehend the evolution and genotyping of CCV, 887 rectal swabs of dogs were collected during 2018-2023. According to p-distance/frequency histograms and phylogenetic trees based on complete genome sequences, the 21 newly obtained Chinese and 84 reference CCV strains were mainly divided into 7 subtypes (CCV-1a, CCV-1b, CCV-1c, CCV-1d, CCV-1e, CCV-2a, and CCV-2b). Among the 21 newly obtained CCVs, 9 strains belonged to CCV-1d, 2 strains belonged to CCV-1b, and the remaining strains belonged to CCV-1c. Recombination analysis indicated that recombination events occurred between CCV strains of different subtypes, hosts, and countries. The CCV capsid protein features 19 variable sites, with 2 sites (T58Q, P239A) displaying regional specificity and 3 (Q57T, E150Q, and T195Q) manifesting subtype specificity. Therefore, this genotyping analysis provides a reference for the molecular characteristics of CCV strains found globally.
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