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Updated: Jun 10, 2025

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Advances in the transport of oral nanoparticles in gastrointestinal tract
Tingting Song1, Lu Yuan1, Jie Wang2
1Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266071, China.
Abstract:
Biological barriers in the gastrointestinal tract (GIT) prevent oral absorption of insoluble drugs. Recently, significant progress has been made in the development of various nanoparticles (NPs) designed to enhance the efficacy of oral drugs. However, the mechanism underlying the intracellular transport of NPs remains unclear, and there are still limitations to improving the oral bioavailability of drugs. This article reviews the challenges faced in the absorption of oral NPs, proposes strategies to overcome these barriers, and discusses the future prospects.
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