Ag quantum dots-doped poly (vinyl alcohol)/chitosan hydrogel coatings to prevent catheter-associated urinary tract...

The prevention of catheter-associated urinary tract infections (CAUTIs) significantly impacts the reduction of morbidity and mortality associated with the use of indwelling urinary catheters. This study focused on developing an antibacterial double network hydrogel coating for latex urinary catheters, which incorporated Ag quantum dots (Ag QDs) in a polyvinyl alcohol (PVA)-chitosan (CS) double network hydrogel matrix. The PVA-CS-Ag QDs, referred to as the PCA hydrogel coating exhibited excellent mechanical and physiochemical properties with controlled release of Ag QDs. The antibacterial properties of the PCA hydrogel-coated urinary catheters were studied against both gram-negative Escherichia coli (E. coli, ATCC25922) and gram-positive Staphylococcus aureus (S. aureus, ATCC29213). The continuous release of CS oligomers and Ag QDs from the hydrogel coating contributed to the synergistic antibacterial and antiadhesion effects. Measurements of the Ag release rate revealed that even after 30 days, the concentration of Ag QDs from the PCA hydrogel-coated urinary catheters remained significantly higher than the effective antibacterial concentration of the total Ag (0.1 μg·L^-1). These results indicated that the PCA hydrogel coating not only efficiently prevented bacteria attachment, but also exhibited long-term antibacterial activity, thereby inhibiting biofilm formation. Furthermore, the PCA hydrogel-coated urinary catheter demonstrated excellent biocompatibility and hemocompatibility. Overall, this novel PCA hydrogel-coated urinary catheter, with its exceptional antibacterial properties, holds great potential in reducing the incidence of CAUTIs.