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Validation of the Cholinergic Urticaria Activity Score (CholUAS)
Pia Schnarkowski1, Pascale Salameh2, Eva Grekowitz1
1Institute for Allergology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
The Journal of Allergy and Clinical Immunology. in Practice
|October 18, 2024
Summary
The Cholinergic Urticaria Activity Score (CholUAS) has been validated for assessing disease activity in patients with Cholinergic Urticaria (CholU). This validated tool demonstrates reliability and is ready for clinical use.
Area of Science:
- Dermatology
- Allergology
- Clinical Trials
Background:
- Cholinergic urticaria (CholU) causes itchy skin reactions triggered by sweating.
- The CholU activity score (CholUAS) lacks validation for assessing disease activity.
Purpose of the Study:
- Validate the CholU activity score (CholUAS).
- Develop an English version of the CholUAS.
- Provide scoring instructions for the CholUAS.
Main Methods:
- Cognitive debriefing of the CholUAS was conducted.
- 75 CholU patients used the CholUAS for 7 days, underwent provocation tests, and completed questionnaires.
- A scoring protocol for the weekly CholUAS (CholUAS7) was developed and tested for validity and reliability.
Main Results:
- The final CholUAS includes 3 scoring questions and 1 global question.
- The weekly CholUAS7 demonstrated excellent test-retest reliability and good correlation with anchor instruments.
- Age and disease duration did not significantly influence CholUAS7 results.
Conclusions:
- The validated CholUAS is suitable for clinical trials.
- The validated CholUAS is ready for routine clinical practice.
